![]() Before we explore epigenetics, we need to review the foundational field of genetics. ![]() Without much fanfare, our understanding of epigenetics has been a significant paradigm shifter. This study is but one of a growing number of publications demonstrating the essential role of epigenetics in animal development, health, and disease. ![]() The team then demonstrated that treating the mice during exposure to early life stress with pinometostat, a drug currently in clinical trials to treat acute myeloid leukemia in humans, inhibited the enzyme responsible for this epigenetic methylation modification and decreased the effect of early-life stress exposure on stress later in life. ![]() In the May 2021 issue of Nature Neuroscience, a research team at Icahn School of Medicine at Mount Sinai Health System in New York City made a fascinating discovery: Early life stress in mice resulted in an epigenetic modification of methyl groups on histone-3 in neurons in the nucleus accumbens, which in turn led to a lifelong increase in the mice’s vulnerability to stress. ![]()
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